This is a prospective observational pilot study of 10 patients who received a cannabinoid-based medication. The inclusion criteria were patients with dementia from different origins (Alzheimer disease, vascular, mixed) with persisting behavior problems (Neuropsychiatric Inventory [NPI] score >10) notwithstanding optimal conventional treatment and consent obtained from the legal representative. The exclusion criteria included unstable somatic disorders with frequent changes in prescriptions, severe cardiac insufficiency or unstable heart rhythm, symptomatic orthostatic hypotension, receiving tricyclic antidepressants, fluoxetine, or carbamazepine, and change in psychotropic medication in the last week.
"The effect of CBD is very unusual. As we have said, many children with ASD display aggressive behaviour and often self-harm. The "conduct normalising" effect is of great interest, since there are no signs of sedation; patients remain properly alert and have no difficulty remaining so. However, in many cases their behaviour is stabilised (though I must reiterate that it is always necessary to assess the severity of the patient's condition).
Some patients acquire skills they had either lost or never had, such as getting dressed on their own, interacting with the tablet, listening to music and paying attention to their surroundings when out walking. They are less inclined to reject physical contact and may even give hugs, possibly for the first time in years. Their facial expressions improve and they can hold eye contact.
Many children with ASD seem to be unhappy and to be in constant pain or suffering. However, once they start treatment this situation appears to change — or at least improve. Some smile or even laugh!"
Policies will be affected globally and reform inspired at the national level
YZ: What makes the endocannabinoid system interesting and exceptional in your opinion?
RP: We know that the endocannabinoid system is involved in many different bodily processes. Interestingly, cannabinoids are made in the body only when and where they are needed to produce particular effects, effects that are often beneficial. Also, they are not stored in the body, and indeed, shortly after interacting with their pharmacological targets, they are broken down by enzymes. The consequences of exposing the body to cannabis are of course quite different, because when people take cannabis the THC it contains indiscriminately activates all cannabinoid receptors in the body at the same time. Such "flooding" of the endocannabinoid system does not occur when endocannabinoids are released endogenously because they are then only produced when and where needed so that their effects on bodily processes are much more selective, resulting for example in "autoprotective" effects such as the alleviation of pain.
5 times the number of nurses in the US than doctors. Most trusted profession and the person who spends THE MOST time with patients.
Back in July of 2017, I was approached by a independent publishing company, Ulysses Press, looking to find someone to author a book on the use and benefits of CBD oil. Now, for those who know me, you know that my initial reaction was anything but glee, yes, yes, I was totally floored... but as a nurse and an advocate I couldn't see myself writing a book solely about CBD. So, as I explained to my editor, the story about cannabidiol had to include the story about cannabis. They said yes and so on September 18, 2017 our book would be released. Our = Lauren Wilson & myself. Lauren has been the best co-author a girl like me could have ever wanted! I couldn't be more excited to say our book is available for pre-order @ local bookstores, Barnes and Noble , & Amazon. If you have ever wondered about cannabis or CBD, pick this book up. It will help you sort out the ever increasing maze and market of cannabis therapeutics.
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